NIF3L1 and macular degeneration: In the NIF3L1 (transcriptional activator NGG1 Interacting Factor 3 Like 1) GWAS, the cis sentinel SNP, rs10931931, (effect allele T, effect size = 0.87, p = 6.3 × 10−12) was found to be causally linked to macular degeneration and decrease its risk (MR effect size −0.11, MR p = 2.0 × 10−6), with no effect in reverse MR.