LTK and type 2 diabetes mellitus: This SNP was shown to causally affect type-2 diabetes risk, mediated by LTK (MR effect size 0.054, MR p = 6.4 × 10−6), there is no effect in reverse MR, and the association passed the colocalisation sensitivity test with a posterior probability of colocalisation (H4) of 0.95 (Fig. 5C, D).