ENO2 and neoplasm: Among the clinical and metabolic parameter predictors, tumor histology (odds ratio [OR] 0.535, 95% CI 0.310–0.921; p < 0.05) and neuron-specific enolase (NSE; OR 1.735, 95% CI 1.003–3.001; p < 0.05) were significantly associated with PD-L1 positivity (ESM Table 1).