LRRK2 and colitis: Park et al. previously showed that BAC humanized LRRK2 G2019S overexpressing rats had an increased presence of immature myeloid cells with suppressive activity on Th17 cell differentiation in the gut, in response to acute (trinitrobenzene sulfonic acid (TNBS)-induced) and chronic (DSS-induced) colitis, relative to background strain rats58.