In CNSm of NSCLC, main T/NK cells types were annotated into 16 cell states according signature genes of T/NK cells, including two CD8+ effector memory clusters (CD8Tem_CCL and CD8Tem_GZMK) and three CD8+ effector clusters (CD8Tef_GZMBL, CD8Tef_GZMAL and CD8Tef_GZMAH), exhibiting extensive heterogeneity of tumor-infiltrating T cells (Fig. 2a, b; Supplementary Fig. S2a). The gene discussed is CD8A; the disease is neoplasm.