HTRA1 and age-related macular degeneration: For example, cluster A1 exhibited higher expression of HTRA1, which has been associated with an increased risk of AMD (Lin et al., 2018) and of the long noncoding RNA Linc01833, a biomarker of immune infiltration that is expressed in both cultured and native human RPE cells (Liu et al., 2023a; Postnikova et al., 2019).