CDKN1C and IMAGe syndrome: Notably, SMS NPCs showed overexpression of CDKN1C and underexpression of CDK18. Gain-of-function mutations of CDKN1C cause the IMAGE syndrome (MIM: 614732) by inducing cell-cycle arrest at G1,76 and CDK18 prevents replication stress and maintains genomic stability (Figure S14E).77