,22 Thus, it has been demonstrated that the presence of antibodies directed against thyroid peroxidase (TPO) and thyroglobulin (TG) at baseline and the early stage of treatment may increase the risk of ICI-induced thyroid dysfunction.23, 24, 25, 26, 27 Similarly, patients who developed diabetes on ICI treatment displayed antibodies reactive against islet cell antigen and glutamic acid decarboxylase-65.28 The gene discussed is TPO; the disease is diabetes mellitus.