However, when provided with additional immunoreceptor tyrosine-based activation motif signaling via an anti–B7-H3 mAb/Fc receptor axis, stIL15-γδ T cells can overcome cancer cell signaling repression, activate canonical γδ T-cell PTM flux, and increase cancer cell killing over AIC alone (Fig. 7, right). The gene discussed is CD276; the disease is cancer.