CD276 and colorectal cancer: To investigate whether B7-H3 mAb cytotoxicity occurs through ADCC and/or blockade of immune checkpoint inhibition, we cocultured stIL15-γδ T cells with colorectal cancer PDOs with anti-B7-H3 IgG1 and an isogenic clone containing a mutated Fc domain that has a significantly reduced affinity for FcγRs on γδ T cells.