Using a B7-H3KO PDO, we demonstrated that ADCC was B7-H3 antigen-specific and that the presence of B7-H3 in the parental PDO did not reduce the AIC performance of stIL15-γδ T cells (Fig. 2E), despite reports that B7-H3 may inhibit the cytotoxicity of γδ T cells via downregulation of IFNγ and granzyme B in colorectal cancer (65). Here, IFNG is linked to colorectal cancer.