IL15 and colorectal cancer: However, γδ T cells engineered to express an IL15Rα–IL15 fusion protein (stabilized IL15, stIL15; refs. 8, 26) are cytotoxic against colorectal cancer PDOs but can be reciprocally immunomodulated by PDOs in an ITH-specific manner, including global rewiring of γδ T-cell PTM signaling networks.