TPM3 and cancer: Foremost upregulated were proteins that structurally reorganize actin into stable filaments and bundles (figure 3B) such as fascin-1, which ensures actin bundle stability by binding to F-actin at regular intervals [37], filamins A and C, known to be involved in non-covalent cross-linking of F-actin [38], and tropomyosin 3 and 4, as a master regulator of individual F-actin filament function, with isoforms 3 and 4 most characteristic for invasive cancers [39].