Numerous variables, including tumor size, histologic type, histologic grade, age at diagnosis, pTNM (pathological Tumor, Node, Metastasis) staging, lymph node metastasis, and molecular profiles (such as the p53 gene, human epidermal growth factor receptor 2/neu (HER2/neu), and others), influence the prediction of breast cancer [1,6]. The gene discussed is ERBB2; the disease is breast cancer.