In cases where high-grade cytology, high MYC (>40%) and BCL2 (>50%) expression, and the GCB phenotype are present, FISH analysis is recommended to assess for MYC and BCL2 rearrangements, which define high-grade B-cell lymphoma with MYC/BCL2 rearrangements, according to the 2022 WHO classification. Here, BCL2 is linked to B-cell non-Hodgkin lymphoma.