CD4+ Th cells assist in activating CD8+ CTLs and also produce cytokines that indirectly contribute to the anti-cancer immune response, common pro-inflammatory cytokines include IL-1, IL-6, IL-8, and tumor necrosis factor-α (TNF-α), while common anti-inflammatory cytokines include IL-4 and IL-10. The gene discussed is IL6; the disease is cancer.