The level of hypoxia inducible factor-1α (HIF-1α) in cancer is inversely proportional to the prognosis of patients (22), and propofol can inhibit the translation process of mRNA, thus inhibiting the activity of HIF-1α in cancer cells in a hypoxic environment, which in turn inhibits angiogenesis and cancer cell proliferation and metastasis. This evidence concerns the gene HIF1A and cancer.