Unlike in NPC, where LMP1 activates both canonical and non-canonical NF-κB pathways primarily via TRAF2, recent findings suggest that in PLEC, TRAF3 downregulation may drive more sustained non-canonical NF-κB signaling, which may contribute to a more immunosuppressive tumor environment and resistance to apoptosis in PLEC. The gene discussed is PDLIM7; the disease is nasopharyngeal carcinoma.