Indeed, we showed in this study that the PD-1 BiKE could deplete the T cell lymphoma that grows in the bone marrow and primary T cells in vivo. Though the presence of NK cells in autoimmune disease tissue may vary by disease, we found that NK cells were present in both the brains and spinal cords of EAE mice (Supplementary Figure S5) similar to other reports (67, 68), which may allow for BiKE-mediated T cell depletion at the site of inflammation in the CNS of these mice. This evidence concerns the gene BMP2K and T-cell non-Hodgkin lymphoma.