It has been confirmed that cancer cells induce neutrophil polarization via exosomal pathways, driving their conversion to pro-tumor phenotypes phenotypes.A research showed that exosomes derived from colorectal cancer (CRC) facilitate the circulation of PACRGL and promote neutrophil differentiation to the N2 phenotype via the miR-142-3p/miR-506-3p-TGF-β1 axis. This evidence concerns the gene TGFB1 and cancer.