<h4>Objective</h4>This study evaluated C-reactive protein (CRP) in hospitalized patients with bladder cancer (BC) and explored the predictive value of CRP for venous thromboembolism (VTE), combining CRP and D-dimer (D-D) levels to improve the ability to predict the risk of VTE in BC patients, thereby better guiding clinical prevention and treatment of this disease.<h4>Methods</h4>Clinical data from 4,438 patients with BC admitted between January 2015 and December 2020 were reviewed. Here, CRP is linked to venous thromboembolism.