The aim of this work was to evaluate the associations of polymorphisms in the TNF-α, IL-6, IL-8, IL-10, CCL5 and CXCL6 genes with COVID-19 outcomes and with the serum levels of IFN-α, IFN-γ, TNF-α, IL-1Ra, IL-6, IL-7, IL-10, CCL2, CCL3, CXCL8, CXCL10 and GCSF. This evidence concerns the gene CSF3 and COVID-19.