This study highlights the associations of the IL-6 rs1800796 (-572 G/C), IL-10 rs1800871 (-819 C/T), rs1800872 (-592 C/A) and CCL5 rs2107538 polymorphisms with fatal COVID-19 outcomes and elevation of cytokines (CCL-2, IL-6, IL-10 and CXC-L10) plays a crucial role in the pathogenesis of COVID-19. This evidence concerns the gene CCL5 and COVID-19.