Interestingly, our study also showed that shLGALS1 can significantly inhibit the expression of PPARγ and change the protein level expression of E-cadherin and Snail in HNSCC cells, which indicates that LGALS1 may promote cell migration by upregulating EMT-related pathways through lipid synthesis. This evidence concerns the gene SNAI1 and head and neck squamous cell carcinoma.