S100A8, S100A9, and S100A12 interact with toll-like receptors and G protein-coupled receptors [these pathways were differently altered by exercise in ALL in remission compared to controls, (Figure 4, Table 3)] to regulate inflammatory responses in innate immune cells (43, 44), while a higher S100A8 and S100A9 protein expression in NK cells induces their activation (45). This evidence concerns the gene S100A9 and acute lymphoblastic leukemia.