RUNX2 and acute lymphoblastic leukemia: Two pathways (“Th2 Pathway” and “Regulation of the Epithelial Mesenchymal Transition by Growth Factors Pathway”) were inhibited in NK cells from children with ALL in remission compared to controls (Z-score values of activation -0.82 and -0.33 respectively), while two pathways (“Epithelial Adherens Junction Signaling” and “Transcriptional regulation by RUNX2”) were activated in the former (Z-score values of activation 1.13 and 0.45 respectively) (Figure 3).