In addition, the MeTIL score is a score calculated based on DNA methylation and is used to assess tumor-infiltrating lymphocytes (TILs), especially CD8+ TILs (45), high levels of TILs contribute to increased responsiveness to neoadjuvant chemotherapy and survival in BC patients, especially in HER2-positive and TNBC breast cancer patients (40). Here, CD8A is linked to breast cancer.