GSVA of KEGG pathways showed that metabolism-related pathways (e.g., aminoglycan and nucleotide glucose metabolism, glycolytic gluconeogenesis) and tumor growth pathways (e.g., cell cycle and DNA replication) were enriched in high-risk patients, whereas immunity-related pathways (JAK STAT signaling, cytokine-receptor interactions, and primary immune deficiencies, etc.)were enriched in patients with low-risk groups (Figure 8F). This evidence concerns the gene SOAT1 and Immunodeficiency.