These factors cooperatively preserve DCs in an immature state, further aggravating immune suppression in TME (146, 150); and d) Downregulation of Cytotoxic T-cell Responses: STAT3 activation plays a fundamental role in suppressing cytotoxic CD8+ T-cell responses, empowering tumor immune evasion, this ensues through the induction of immunosuppressive cytokines such as IL-10 and TGF-β, which create an inhibitory TME that impairs T-cell activity (151). The gene discussed is CD8A; the disease is neoplasm.