Oncogenic miRNAs (oncomiRs), such as miR-21 and miR-181b, are overexpressed in OSCC, encouraging malignant transformation by downregulating the mRNA expression of tumor suppressors like PTEN (Phosphatase and Tensin Homolog) and PDCD4 (Programmed Cell Death 4) and heightening inflammation-driven tumor progression. The gene discussed is PTEN; the disease is neoplasm.