PIK3CA and neoplasm: In addition, PI3-K (phosphatidylinositol 3-kinase) which is involved in cell survival, proliferation, and metabolism, DAPK (death-associated protein kinase), which has a role in tumor suppression and apoptosis, and MGMT (O6-methylguanine-DNA methyltransferase), which is involved in cell genomic stability and DNA repair are also implicated in OSCC (59).