STAT3 and neoplasm: In OSCC tissues, phosphorylated STAT3 (p-STAT3) is positively concurrent with markers of MDSCs, such as CD33 and CD14; high p-STAT3 levels are associated with increased MDSC accumulation and enhanced immunosuppressive activity in the TME (146); c) Suppression of Dendritic Cell (DC) Function: STAT3 hyperactivation disrupts DC maturation, weakening their ability to present antigens and activate T cells, while immature DCs accumulate in the TME due to STAT3 signaling and immunosuppressive factors, including regulatory T-cells, tumor-associated macrophages, and hypoxic conditions.