These miRNAs displayed pathogenic roles in DKD by creating an intricate network with targeted genes such as FOXO1, MMP-9, Smad7, TIMP3, Cdk6, and IMP3 and signaling cascades, including PKC, TGF-β/NF-κB/SMAD, Akt/TORC1, CADM1/STAT3, and the AGE-RAGE regulatory cascade, resulting in extracellular matrix deposition, cytoskeletal remodeling, epithelial-to-mesenchymal transition, inflammation, and fibrosis [74–76]. This evidence concerns the gene FOXO1 and diabetic kidney disease.