Results: Genetically predicted PNPLA3 inhibition significantly increased the risk of gout (OR: 1.83, 95% CI: 1.49 to 2.26, p = 1.44 × 10−8), idiopathic gout (OR: 2.42, 95% CI: 1.60 to 3.65, p = 2.81 × 10−5) and urate (OR: 1.12, 95% CI: 1.01 to 1.23, p = 2.56 × 10−2), but not with gout due to impairment of renal function (OR: 1.25, 95% CI: 0.37 to 4.22, p = 7.23 × 10−1). This evidence concerns the gene PNPLA3 and gout.