IL13 and Myocardial fibrosis: In animal models such as the IL-13 knockout mouse model of myocardial infarction and the diabetic cardiomyopathy model, M2 macrophages are reduced in injured cardiac tissues, but myocardial fibrosis is aggravated, which in turn suggests an inhibitory effect of M2 macrophages on myocardial fibrosis in these models (85, 86).