IL18 and Myocardial fibrosis: First, NF-κB activation induces the accumulation of inflammatory factors (e.g., TNF-α, IL-1β, IL-6, IL-18, etc.)in myocardial tissues, resulting in increased inflammatory response and consequently myocardial injury, which promotes the proliferation of myocardial fibroblasts and collagen deposition, and ultimately induces the onset of myocardial fibrosis.