In addition, overexpression of miR-21 induces myocardial fibrosis by regulating Jagged 1 and dual-specificity phosphatase 8 (DUSP8), and promotes the transformation of CFs to myofibroblasts and myocardial fibers by targeting Jagged1 (29). The gene discussed is DUSP8; the disease is Myocardial fibrosis.