First, NF-κB activation induces the accumulation of inflammatory factors (e.g., TNF-α, IL-1β, IL-6, IL-18, etc.)in myocardial tissues, resulting in increased inflammatory response and consequently myocardial injury, which promotes the proliferation of myocardial fibroblasts and collagen deposition, and ultimately induces the onset of myocardial fibrosis. The gene discussed is TNF; the disease is Myocardial fibrosis.