BYHWD down-regulated IL-18, NLRP3 inflammatory vesicles, and TLR4/NF-κB signaling pathway by inhibiting the TLR4 signaling pathway, and suppressed the expression level of collagen I/III, thereby attenuating cardiac inflammation and myocardial fibrosis after myocardial infarction (262). This evidence concerns the gene IL18 and Myocardial fibrosis.