TGFB1 and Myocardial fibrosis: QSYQ inhibited the TGFβ1/Smads signaling pathway and NLRP3 inflammatory vesicle expression, and significantly suppressed monocyte infiltration and macrophage polarization toward M2, thereby inhibiting MMP-2 and MMP-9 expression and ameliorating I/R induced myocardial fibrosis (268, 269).