Several genes associated with amelogenesis imperfecta have been identified, including amelogenin (AMELX), enamelin (ENAM), matrixmetalloproteinase 20 (MMP20), protein coding: family with sequence similarity 83 member H (FAM83H), WD repeat-containing protein 72 (WDR72), ameloblastin (AMBN), homeobox-protein DLX-3 (DLX3), and kallikrein-related peptidase 4 (KLK4) [4,5]. The gene discussed is ENAM; the disease is amelogenesis imperfecta.