In line with this, Pep2m (PEP; 5 pmol/μl; Lüthi et al., 1999), a peptide that disrupts NSF/GluA2 interaction and reduces surface AMPARs expression (Ralph et al., 2001), induced spatial memory amnesia when administered into dCA1 5-min after non-reinforced spatial memory reactivation. The gene discussed is GRIA2; the disease is amnesia.