AT1 shows a selectiveBET bromodomain protein, BRD4 degradation, and suppression of tumorgrowth in AML. AT1 comprises of the widelyused and well-characterized binder of BET bromodomain proteins, (+)-JQ1, as its POI-targeting warhead, and the VH032ligand, for recruiting the VHL E3 ligase complex. To create the OligoPROTAC, we aimed to attach VH032 tothe 5′-terminus of one DNA oligonucleotide and (+)-JQ1 to the3′-terminus of a complementary DNA oligonucleotide. The gene discussed is DNER; the disease is acute myeloid leukemia.