In colon cancer (Zheng et al., 2022b), NAT10 modulates the FSP1 expression axis via ac4C modification, driving a ferroptosis-suppressive microenvironment characterized by reduced ROS, Fe2+, Malondialdehyde (MDA), mitochondrial matrix condensation, and cristae reduction, indicating that acetylated ac4C modification of FSP1 mRNA correlates with ferroptosis inhibition. Here, NAT10 is linked to colonic neoplasm.