Our findings revealed that certain pathways, notably the PU.1/microRNA-142-3p/ATG5/ATG16L1 and the FOXM1/LINC-ROR feedback loops, are pivotal regulators influencing HCC cell sensitivity to sorafenib, specifically through their roles in modulating autophagy and cellular proliferation (Zhi et al., 2019; Zhang et al., 2018a). The gene discussed is SPI1; the disease is hepatocellular carcinoma.