The Hippo/YAP pathway participates in vascular remodeling processes in cardiovascular diseases such as pulmonary hypertension, atherosclerosis, restenosis, aortic aneurysms, and angiogenesis by altering the production or degradation of the extracellular matrix and regulating the growth, death, and migration of vascular smooth muscle cells (VSMCs) and endothelial cells (Yu et al., 2020; Pulkkinen et al., 2021; Quan et al., 2022; Liu et al., 2023; Kong et al., 2024). The gene discussed is YAP1; the disease is pulmonary hypertension.