CRPPA and malaria: As a recent review highlights, IspD is a compelling drug target not only for malaria, but also for the development of new antibacterials and herbicides.11 However to date, no IspD-targeting antimalarial has shown efficacy in an animal model of infection, including benzoisothiazolones,12 diarylureas,13 and as we previously reported,14 tetrahydro-β-carboline 1.