Diabetes positively regulates APP (4 references; q = 0.00015), NLRP3 (19 references; q = 0.00168), and PVT1 (4 references; q = 0.00755), while negatively regulating CYP2C19 (14 references; q = 0.00372), suggesting its influence on pathways related to inflammation, immune response, and metabolism. The gene discussed is APP; the disease is diabetes mellitus.