ASCC3 is a specific protective factor for rectal adenocarcinoma across various cancer types, particularly in digestive system cancers, and can synergize with several immune-related genes, including JAK1, NFKB1, SEMA5A, NR2C2, CNTF, and CREB1, to influence patient prognosis. The gene discussed is CREB1; the disease is cancer.