NFE2L2 and acute kidney injury: Bardoxolone methyl (BARD), or CDDO-Me, is a synthetic triterpenoid that is derived from oleanolic acid and serves as a potent nuclear factor erythroid 2-related factor 2 (Nrf2) activator that was shown in vitro to have protective effects against cisplatin-induced AKI by mitigating oxidative stress and inflammation (Fig. 1) (Aleksunes et al. 2010; Hasegawa 2017; Camer et al. 2016; Ruiz et al. 2013; Pergola et al. 2011a; Atilano-Roque et al. 2016a; Atilano-Roque et al. 2016b; Yoh et al. 2001; Kurosaki et al. 2022; Mapuskar et al. 2023).