FSTL5 and gout: Whole-genome sequencing studies further identify novel genetic loci (RCOR1, FSTL5-MIR4454) and transporter variants (ABCG2, SLC22A12) associated with early-onset gout, with RCOR1 promoting NLRP3 inflammasome activation and IL-1β release, which are key drivers of gouty inflammation (18).