Additionally, more L-HSD/H-HSD patients self-reported issues with pain/cramps in lower abdomen (hEDS p < 0.001, HSD p = 0.026), constipation (hEDS p < 0.001, HSD p = 0.008), bowel cramps (hEDS p < 0.001, HSD p = 0.039), and GERD (hEDS p = 0.012, HSD p = 0.036) than patients diagnosed with hEDS or HSD (Table 8) indicating that patients with L-HSD/H-HSD have significant gastrointestinal symptoms/comorbidities. This evidence concerns the gene CHST3 and gastroesophageal reflux disease.