Our findings of overlap in allergy/mast cell symptoms in hEDS and HSD are congruent with the recent report by Ritelli et al. who discovered plasma biomarkers in both hEDS and HSD, but not in controls, that are the product of extracellular matrix (ECM) degradation (collagen I and fibronectin fragments) (15). This evidence concerns the gene FN1 and Ehlers-Danlos syndrome, hypermobility type.