CHST3 and allergic disease: Additionally, more L-HSD/H-HSD patients self-reported issues with multiple sensitivities (hEDS p < 0.001, HSD p < 0.001), shortness of breath (hEDS p < 0.001, HSD p < 0.02), sun sensitivity (hEDS p < 0.001, HSD p < 0.008), and wheezing (hEDS p = 0.001, HSD p < 0.01) than patients diagnosed with hEDS or HSD (Table 6) indicating that patients with L-HSD/H-HSD have significant asthma/allergy symptoms and comorbidities.