These abnormalities are closely linked to an increased risk of developing type 2 diabetes mellitus (T2DM), cardiovascular diseases, and certain cancers.<h4>Objective</h4>To systematically evaluate the effects of different exercise modalities-AE, RT, COM, HIIT-and their dosages on the regulation of adipokines (leptin and adiponectin) in individuals with overweight and obesity.<h4>Methods</h4>A comprehensive literature search was conducted across Cochrane, Embase, PubMed, Web of Science, and EBSCO databases for randomized controlled trials (RCTs) published between 2000 and January 2025. This evidence concerns the gene LEP and Obesity.