LEP and obesity due to melanocortin 4 receptor deficiency: These abnormalities are closely linked to an increased risk of developing type 2 diabetes mellitus (T2DM), cardiovascular diseases, and certain cancers.<h4>Objective</h4>To systematically evaluate the effects of different exercise modalities-AE, RT, COM, HIIT-and their dosages on the regulation of adipokines (leptin and adiponectin) in individuals with overweight and obesity.<h4>Methods</h4>A comprehensive literature search was conducted across Cochrane, Embase, PubMed, Web of Science, and EBSCO databases for randomized controlled trials (RCTs) published between 2000 and January 2025.