Studies have found that polydatin has a certain improvement effect on rats with chronic obstructive pulmonary disease, which may be related to inhibiting the Toll-Like Receptor 4 (TLR4) and Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway (Jiang et al., 2015). This evidence concerns the gene TLR4 and chronic obstructive pulmonary disease.