AQP5 and Hyperhidrosis: In mice with the Aqp5 gene knocked out (Figure 5A), we observed that pre-treatment with 50 mg/kg/day of Polydatin for 1 week, followed by the construction of a murine hyperhidrosis model, did not effectively alleviate the symptoms of hyperhidrosis (Figures 5B,C) (A, Vehicle: 47.83 ± 6.37, PLD: 41.33 ± 7.15, p = 0.114; B, Control: 8.83 ± 1.32 μg/mL, Vehicle: 28.79 ± 4.07 μg/mL, PLD: 24.46 ± 4.09 μg/mL, p = 0.178, C, Control: 12.27 ± 1.96 μg/mL, Vehicle: 21.76 ± 3.32 μg/mL, PLD: 18.44 ± 3.21 μg/mL, p = 0.266).