HIF-1α-mediated glycolysis represents a critical pathway contributing to inflammatory activation in ARDS, and both Dachengqi Decoction and N-phenethyl-5-phenylpicolinamide have been shown to exert therapeutic effects by inhibiting this pathway (Shang et al., 2024; Du et al., 2022). The gene discussed is HIF1A; the disease is acute respiratory distress syndrome.