Silencing of LDHB induces sustained mitochondrial DNA damage, and reduces mitochondrial respiratory complex activity and OXPHOS, resulting in reduced levels of mitochondria-dependent metabolites (e.g., TCA intermediates, amino acids, and nucleotides), which inhibits NSCLC development (Deng et al., 2022). The gene discussed is LDHB; the disease is non-small cell lung carcinoma.