We propose a model in which microglial cytoskeletal disorganization, here induced by the deletion of a regulating hub protein, DISC1, impairs phagocytosis, reduces synapse number, and weakens synaptic function within the CA1 region of the hippocampus, ultimately contributing to spatial memory deficits similar to those observed in NDDs including schizophrenia (36). The gene discussed is DISC1; the disease is schizophrenia.