Notably, in myocardial remodeling, although inhibition of TGFβ prevented myocardial fibrosis, it did not ameliorate cardiac dysfunction, and when knockdown of TGFBR2 not only prevented myocardial fibrosis but also ameliorated cardiac dysfunction [64], and it remains unclear whether knockdown of TGFBR1 has a similar effect. The gene discussed is TGFBR1; the disease is Myocardial fibrosis.