This study collected 592 patients admitted to the ICU from 01/01/2020–31/12/2023, and used binary logistic regression analysis to predict the predictive effect of Malignant tumor, Admission ICU unit, CRP, APTT, Any norepinephrine use, Blood.transfusion, Chlorine disinfectant, Tracheotomy on the occurrence of HARTI in ICU patients. The gene discussed is CRP; the disease is cancer.