Relative to the low ACE2 group, the high ACE2 group had greater rates of AKI within the first 48 hours of ICU admission (81.6% vs. 69.6%, p = 0.006), consequent renal replacement therapy (21.3% vs. 11.1%, p = 0.007), ICU mortality (31.9% vs. 17.5%, p = 0.001), and 90-day mortality (51.7% vs. 39.6%, p = 0.018). Here, ACE2 is linked to acute kidney injury.