TFEB and infection: In addition to changes in nutrient status, TFEB is activated by a variety of cellular stresses, including lysosomal damage (Chauhan et al., 2016; Nakamura et al., 2020), mitochondrial damage (Nezich et al., 2015), infection (Visvikis et al., 2014), endoplasmic reticulum (ER) stress (Martina et al., 2016), DNA damage (Brady et al., 2018a), proteasome inhibition (Li et al., 2019a), oxidative stress (Martina et al., 2021), and physical exercise (Mansueto et al., 2017).