Although our prior data show that suppression of cytosolic HSP70 activates the UPR in RMS [10], LINCS data strongly connected this transcriptional signature to loss of ER-resident HSPA5/GRP78/BiP in other cancer cell lines, including YAPC (pancreatic carcinoma), ES2 (ovarian cancer), AGS (gastric carcinoma), and HT29 (colon cancer). Here, HSPA5 is linked to cancer.