In contrast, ANK2 and ANK3 are more widely expressed, including in the central nervous system: ankyrin‐B (ANK2) plays a key role in ion channel organization, with pathogenic variants linked to cardiac arrhythmia (OMIM #600919) and several neurodevelopmental disorders (NDDs); ankyrin‐G (ANK3) serves as a master organizer of the axon initial segment and the nodes of Ranvier, facilitating action potential initiation and propagation along the axon.2, 3, 4. This evidence concerns the gene ANK3 and neurodevelopmental disorder.