In contrast, ANK2 and ANK3 are more widely expressed, including in the central nervous system: ankyrin‐B (ANK2) plays a key role in ion channel organization, with pathogenic variants linked to cardiac arrhythmia (OMIM #600919) and several neurodevelopmental disorders (NDDs); ankyrin‐G (ANK3) serves as a master organizer of the axon initial segment and the nodes of Ranvier, facilitating action potential initiation and propagation along the axon.2, 3, 4. Here, ANK3 is linked to cardiac arrhythmia.