Boosting specific PTP1B-dependent pathways may offer new strategies for enhancing host defense while minimizing fungal-induced immunopathology.IMPORTANCESystemic <i>Candida albicans</i> infections are a leading cause of hospital-acquired morbidity and mortality, particularly in immunocompromised individuals and patients receiving immunosuppressive treatments. Here, PTPN1 is linked to infection.