Similarly, in anEscherichia coli peritonitis model of infection, expressionof the different adenosine receptors changed over time, where A1R peaked firstat 12 hours post-challenge followed by a decrease, A2AR peaked second at 24hours then decreased by 48 hours, and A2BR did not increase until after 24hours, suggesting that these receptors play a time-dependent role in infection(96). This evidence concerns the gene ADORA2A and infection.