While age and motor severity are established predictors, the genetic role remains underexplored.<h4>Objective</h4>To evaluate the influence of major genetic variants on PA development in PD over 4 years.<h4>Methods</h4>We analyzed 429 patients from Parkinson's Progression Markers Initiative, including GBA, LRRK2 and SNCA mutation carriers. Here, SNCA is linked to Parkinson disease.