Given the increasingly recognized roles of mast cells [5] and M2 macrophages [6] in severe CRSwNP, transcriptional activity in the DEGs encoding mast cell carboxypeptidase A3 (CPA3), and macrophage‐derived extracellular matrix remodeling metallopeptidases such as ADAM19, MMP3, and MMP12 may be promising targets. Here, MMP3 is linked to chronic rhinosinusitis with nasal polyps.