CPA3 and chronic rhinosinusitis with nasal polyps: Given the increasingly recognized roles of mast cells [5] and M2 macrophages [6] in severe CRSwNP, transcriptional activity in the DEGs encoding mast cell carboxypeptidase A3 (CPA3), and macrophage‐derived extracellular matrix remodeling metallopeptidases such as ADAM19, MMP3, and MMP12 may be promising targets.